Clinical department

Nuclear Medicineand Theranostics

A revolutionary approach where the same radioactive molecule both finds cancer cells throughout your body and delivers a targeted dose of radiation to destroy them — sparing healthy tissue.

Nuclear Medicine and Theranostics

Department overview

Diagnosis and therapy, combined

The word theranostics blends therapy and diagnostics. A specially designed molecule seeks out specific targets on cancer cells. First, a low-dose version is injected to image the tumour and confirm the target is present. Then, a therapeutic version delivers radiation directly to every site of disease — even spread invisible on conventional CT.

This precision means fewer side effects compared to traditional chemotherapy or external radiotherapy, and it can treat disease throughout the entire body in a single treatment cycle.

Message from the Head of Department

“We carry forward a legacy that began in 1957 when our founding pioneer, Dr. V.M. Sivaramakrishnan, established one of India’s first nuclear medicine centers. Today, we honor that vision by combining our six decades of experience with cutting-edge molecular imaging and therapeutic technologies. Our department stands at the unique intersection of physics, chemistry, and medicine—using the power of radiopharmaceuticals to see what others cannot see and treat what others cannot reach. Every nuclear medicine scan, every radionuclide therapy, and every diagnostic procedure we perform is driven by one commitment: to provide our patients with the most accurate diagnosis and effective treatment possible. We have a dedicated team of physicians, physicists, and technologists who work tirelessly to ensure that each patient receives personalized, evidence-based care with compassion and dignity.”

Dr. Ashok Kumar RConsultant & Incharge - Department of Nuclear Medicine
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WHY IT MATTERS

Key benefits of nuclear medicine imaging

  • Earlier detection — identifies cancer and disease at the molecular level, often years before structural changes appear on CT or MRI
  • Whole-body in one scan — maps disease throughout the entire body in a single session, enabling complete cancer staging without multiple procedures
  • Guides treatment decisions — confirms whether a tumour is metabolically active, identifies the best biopsy site, and monitors response to therapy
  • Non-invasive and safe — delivers targeted diagnostic information with radiation doses similar to a few months of natural background exposure
  • Unique functional information — assesses organ function (heart, kidney, thyroid, brain) that cannot be obtained from structural imaging alone
HOW IT WORKS

The theranostics pathway

1

Diagnostic scan (PET/CT)

A small amount of radiotracer is injected. It binds to receptors on tumour cells. A PET/CT scan creates detailed 3D images showing every cancer deposit in the body.

2

Eligibility assessment

The nuclear medicine team reviews your scan. If tumour uptake is confirmed, you are a candidate for therapy — the 'see before you treat' principle unique to theranostics.

3

Targeted radionuclide therapy

The same molecule, now carrying a therapeutic isotope, is injected. It locks onto cancer cells and delivers a lethal radiation dose locally while decaying harmlessly elsewhere.

4

Response evaluation

After each cycle, imaging is repeated to assess response. Treatment is adapted based on how the disease responds — a truly personalised approach.

Conditions we treat

  • Prostate cancer — PSMA-targeted therapy and Radium-223 for bone metastases
  • Neuroendocrine tumours — PRRT with Lu-177 DOTATATE
  • Thyroid cancer and hyperthyroidism — Radioiodine (I-131)
  • Primary and secondary liver cancer — SIRT with Y-90 microspheres
  • Bone metastases with pain — Samarium-153 or Radium-223
  • Inflamed or painful joints — Radiosynovectomy
  • Pheochromocytoma and paraganglioma — MIBG therapy
  • Next generation alpha therapy with Ac225

Treatment Options

Our department provides the full spectrum of radionuclide therapies, each precisely matched to the condition being treated.

TherapyIsotopeCondition treatedCategory
Lu-177 PSMA therapyLutetium-177/ AC225Metastatic castration-resistant prostate cancerProstate / bone
PRRTLu-177 DOTATATE / AC225Neuroendocrine tumours (NETs)Neuroendocrine / GI
Radioiodine therapy (I-131)Iodine-131Thyroid cancer & hyperthyroidismThyroid
Radium-223 therapyRadium-223Bone metastases in prostate cancerProstate / bone
SIRTY-90 microspheresPrimary & secondary liver cancerLiver
RadiosynovectomyY-90 / Re-186 / Er-169Joint pain from arthritis or cancerJoint
Samarium-153 therapySamarium-153Widespread bone metastases — pain reliefPain palliation

When To Visit

When to visit

Clinical Indications

  • Referred by treating oncologist for diagnostic PET/CT imaging (FDG, PSMA, DOTA)
  • Evaluation for targeted radionuclide therapy (Lu-177 PSMA, PRRT, Radioiodine, SIRT, or Radium-223)

Facilities & capabilities

GE Hawkeye Gamma Camera

Advanced dual-head gamma camera with SPECT capability for high-quality nuclear imaging of all organs

GE NM 630 Discovery Machine

State-of-the-art nuclear medicine imaging system for precise diagnostic scans

Gamma Spectroscopy Machine

Analyzes energy spectrum of gamma radiation for quality control and radiopharmaceutical purity testing

ITLC Gamma Analyser Machine

Instant Thin Layer Chromatography system for radiopharmaceutical quality assurance

Multiple Laser X-ray Film Printers

High-quality medical image printing systems for producing diagnostic-grade hard copies of nuclear medicine scans

Gamma Probe Machine

Intraoperative radiation detection device used during sentinel lymph node biopsy and tumor localization surgery

High Dose Therapy Ward

Dedicated isolation facility with proper radiation shielding for radioiodine therapy and other therapeutic nuclear medicine procedures

Two-Bedded Therapy Ward

Comfortable patient rooms equipped with all necessary amenities and radiation safety features

Fume Hood in Therapy Ward

Ventilated enclosure for safe handling of radioactive materials in patient care areas

Dose Calibrator Machine

Precisely measures radioactivity of radiopharmaceuticals before administration to ensure accurate patient dosing

Hand and Foot Radiation Monitor

Detects radioactive contamination on hands and feet of staff and patients for safety compliance

Pocket Dosimeter

Personal radiation monitoring device worn by staff to track individual radiation exposure levels

Multiple LED L-Bench (Fume Hood)

Laminar flow workstations with LED lighting for safe handling and preparation of radiopharmaceuticals

Contamination Monitor

Detects and measures radioactive contamination on surfaces and equipment

Area Radiation Monitor

Continuously monitors ambient radiation levels in the department to ensure staff and patient safety

Lead-Lined Waste Bin

Shielded containers for safe disposal of radioactive waste materials

Lead Aprons

Personal protective equipment providing radiation shielding for staff during procedures

Image Processing and Reporting

Technologist processing nuclear medicine images for diagnostic interpretation

Frequently asked questions

01

Is theranostics safe?

02

Will I be radioactive after treatment?

03

How many cycles are needed?

04

Can it be combined with other treatments?

Contact Nuclear Medicine and Theranostics

Consultant & Incharge - Department of Nuclear Medicine

Dr. Ashok Kumar R

nm@cancerinstitutewia.org
Book Appointment
Cancer Institute (WIA), Adyar campus